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Dietary quality amplifies drug effects: GLP-1 receptor agonists reduce appetite and caloric intake, but the nutritional quality of consumed calories still matters for health outcomes

Nikolaidis LA, Elahi D, Hentosz T, et al.: Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy

Wegovy is inducing an average 15% reduction in baseline body weight, roughly twice as much as other types of FDA-approved weight-loss medications, says Wadden Ozempic is the same drug but it has only been FDA-approved for treating diabetes and it comes in a lower dose (the maximum prescribed dose of Ozempic is 2.0 mg)

M2 macrophages are anti-inflammatory, promoting tissue repair and resolution of inflammation

This is why combining them (CagriSema) produces greater weight loss than either alonethe mechanisms are complementary rather than redundant